{"id":3843,"date":"2025-07-24T17:01:40","date_gmt":"2025-07-24T21:01:40","guid":{"rendered":"https:\/\/www.accessforkidscancer.ca\/?post_type=theme-project&p=3843"},"modified":"2025-11-21T11:47:51","modified_gmt":"2025-11-21T16:47:51","slug":"diagnostic-et-intervention-de-precision-pour-la-leucemie-infantile","status":"publish","type":"theme-project","link":"https:\/\/www.accessforkidscancer.ca\/fr\/projects\/diagnostic-et-intervention-de-precision-pour-la-leucemie-infantile\/","title":{"rendered":"Diagnostic et intervention de pr\u00e9cision pour la Leuc\u00e9mie <\/span>infantile"},"content":{"rendered":"

La leuc\u00e9mie chez les nourrissons est une forme rare et agressive de cancer du sang qui survient chez les enfants de moins de 12\u00a0mois. Contrairement \u00e0 la leuc\u00e9mie chez les enfants plus \u00e2g\u00e9s, l\u2019apparition pr\u00e9coce de la maladie survient pendant une fen\u00eatre critique de la croissance et du d\u00e9veloppement de l\u2019enfant. Elle est marqu\u00e9e par une diversit\u00e9 frappante de changements g\u00e9n\u00e9tiques, ce qui la rend particuli\u00e8rement difficile \u00e0 traiter. Pourtant, parce qu\u2019il est si rare, les efforts de recherche dans ce sous-type ont stagn\u00e9. Ainsi, les nourrissons atteints de leuc\u00e9mie continuent d\u2019avoir de faibles taux de gu\u00e9rison par rapport \u00e0 ceux qui ont re\u00e7u un diagnostic de leuc\u00e9mie plus tard dans l\u2019enfance.<\/p>\n

Les progr\u00e8s du profilage g\u00e9nomique ont montr\u00e9 que la leuc\u00e9mie infantile est beaucoup plus vari\u00e9e qu\u2019on ne le croyait. Nous savons maintenant qu\u2019il existe de nombreux sous-types cach\u00e9s et que chacun de ces sous-types peut se comporter diff\u00e9remment, r\u00e9agir diff\u00e9remment aux traitements et comporter ses propres risques. Cependant, malgr\u00e9 ces puissantes avanc\u00e9es, la plupart des enfants sont toujours trait\u00e9s avec les m\u00eames traitements standard, qui souvent ne fonctionnent pas bien pour les formes les plus agressives et peuvent causer de graves effets secondaires \u00e0 long terme pour les survivants.<\/p>\n

Pour changer cela, le projet met sur pied un groupe de travail pancanadien multidisciplinaire d\u00e9di\u00e9 \u00e0 l\u2019\u00e9tude de la leuc\u00e9mie infantile. En travaillant au sein d\u2019une \u00e9quipe unifi\u00e9e de scientifiques, de cliniciens et de personnes ayant une exp\u00e9rience v\u00e9cue, l\u2019\u00e9quipe du projet esp\u00e8re acc\u00e9l\u00e9rer les d\u00e9couvertes de la recherche et am\u00e9liorer les soins actuels aux patients afin d\u2019offrir un nouvel espoir aux familles actuelles et futures confront\u00e9es \u00e0 cette maladie d\u00e9vastatrice.<\/p>\n

Ce projet vise sp\u00e9cifiquement \u00e0\u00a0:<\/p>\n

    \n
  1. normaliser la collecte d\u2019\u00e9chantillons annot\u00e9s cliniquement de nourrissons atteints de leuc\u00e9mie tout au long du parcours du patient;<\/li>\n
  2. assurer un acc\u00e8s \u00e9quitable au profilage g\u00e9nomique et prot\u00e9omique de base des \u00e9chantillons de nourrissons atteints de leuc\u00e9mie au moment du diagnostic;<\/li>\n
  3. effectuer un profil de sensibilit\u00e9 aux m\u00e9dicaments au moment du diagnostic et de la rechute;<\/li>\n
  4. cartographier l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 de la leuc\u00e9mie chez les nourrissons afin d\u2019identifier les cellules d\u2019origine et les sous-populations r\u00e9sistantes aux m\u00e9dicaments;<\/li>\n
  5. effectuer un profilage prot\u00e9omique int\u00e9gr\u00e9 d\u2019\u00e9chantillons pour identifier de nouveaux biomarqueurs th\u00e9rapeutiques et obtenir de nouvelles connaissances mol\u00e9culaires;<\/li>\n
  6. constituer un comit\u00e9 multidisciplinaire de m\u00e9decine de pr\u00e9cision fonctionnelle sur les tumeurs afin d\u2019avoir une incidence sur la prise en charge des patients et d\u2019\u00e9tablir les priorit\u00e9s de recherche.<\/li>\n<\/ol>\n

    Ce projet constituera une premi\u00e8re \u00e9tape vers l\u2019int\u00e9gration de la m\u00e9decine de pr\u00e9cision \u00e0 d\u2019autres cas de leuc\u00e9mie p\u00e9diatrique de mani\u00e8re harmonis\u00e9e \u00e0 l\u2019\u00e9chelle du Canada. On esp\u00e8re que le travail pr\u00e9paratoire de ce projet se traduira par des efforts similaires pour d\u2019autres leuc\u00e9mies \u00e0 haut risque \u00e0 l\u2019avenir.<\/p>\n

    Partenaires financiers :<\/h4>\n

    Fonds Benoit Lanteigne<\/a> et SIGNATURE 2.0 (Fondation Charles-Bruneau).<\/a><\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"tags":[],"project-category":[125],"class_list":["post-3843","theme-project","type-theme-project","status-publish","hentry","project-category-biologie-du-cancer"],"acf":[],"yoast_head":"\nDiagnostic et intervention de pr\u00e9cision pour la Leuc\u00e9mie infantile - Access<\/title>\n<meta name=\"description\" content=\"ACCESS is organized into seven research themes from understanding cancer development to its diagnosis, treatment, and survivorship and two cross-cutting groups to support all thematic areas.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.accessforkidscancer.ca\/fr\/projects\/diagnostic-et-intervention-de-precision-pour-la-leucemie-infantile\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Diagnostic et intervention de pr\u00e9cision pour la Leuc\u00e9mie infantile - 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