{"id":4748,"date":"2026-10-02T16:23:20","date_gmt":"2026-10-02T20:23:20","guid":{"rendered":"https:\/\/www.accessforkidscancer.ca\/?post_type=theme-project&p=4748"},"modified":"2026-10-02T16:28:15","modified_gmt":"2026-10-02T20:28:15","slug":"evaluation-de-la-podocalyxine-comme-biomarqueur-therapeutique-pour-un-nephroblastome-agressif","status":"publish","type":"theme-project","link":"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/evaluation-de-la-podocalyxine-comme-biomarqueur-therapeutique-pour-un-nephroblastome-agressif\/","title":{"rendered":"\u00c9valuation de la podocalyxine comme biomarqueur th\u00e9rapeutique pour un n\u00e9phroblastome agressif"},"content":{"rendered":"

Le n\u00e9phroblastome, aussi connu sous le nom de tumeur de Wilms (TW), est le cancer du rein le plus fr\u00e9quent chez les enfants; il est principalement diagnostiqu\u00e9 entre un et quatre ans. Bien que la plupart des enfants r\u00e9agissent bien au traitement, un nombre important d\u2019entre eux qui pr\u00e9sentent des formes plus agressives de la maladie courent un risque beaucoup plus \u00e9lev\u00e9 de rechute ou de propagation, ce qui souligne la n\u00e9cessit\u00e9 de meilleurs outils pour identifier et traiter ces cas \u00e0 haut risque. La podocalyxine (PODXL) est une prot\u00e9ine qui joue un r\u00f4le important dans le d\u00e9veloppement r\u00e9nal. Dans de nombreux cancers, des niveaux \u00e9lev\u00e9s de cette prot\u00e9ine sont li\u00e9s \u00e0 une maladie plus agressive. Dans la tumeur de Wilms, les premi\u00e8res d\u00e9couvertes sugg\u00e8rent qu\u2019une forme glyosyl\u00e9e sp\u00e9cifique de cette prot\u00e9ine pourrait \u00eatre pr\u00e9sente (biomarqueur) dans les cellules tumorales les plus agressives.<\/p>\n

Dans ce projet soutenu par le PCMM<\/a>, l\u2019\u00e9quipe de recherche utilisera un anticorps sp\u00e9cialis\u00e9 capable de d\u00e9tecter cette forme unique de podocalyxine. En examinant des \u00e9chantillons de tumeurs chez les patients, l\u2019\u00e9quipe de recherche vise \u00e0 d\u00e9terminer si ce biomarqueur peut aider \u00e0 identifier les tumeurs plus susceptibles de rechuter ou de se propager. S\u2019il r\u00e9ussit, cet anticorps, ainsi que le glyco\u00e9pitope PODXL qu\u2019il reconna\u00eet, pourrait offrir aux cliniciens un nouvel outil puissant pour mieux pr\u00e9dire les r\u00e9sultats et adapter les traitements en cons\u00e9quence.<\/p>\n

Parall\u00e8lement, ce projet cr\u00e9era \u00e9galement une collection de mod\u00e8les de tumeurs vivantes (organo\u00efdes) cultiv\u00e9s \u00e0 partir d\u2019\u00e9chantillons de patients qui pr\u00e9sentent des niveaux \u00e9lev\u00e9s et faibles de PODXL. Ces versions miniaturis\u00e9es des tumeurs reproduisent des caract\u00e9ristiques cl\u00e9s du cancer et peuvent \u00eatre utilis\u00e9es pour tester de nouvelles th\u00e9rapies en laboratoire. Cette biobanque vivante soutiendra les recherches futures pour mieux comprendre la biologie des tumeurs de Wilms et cerner des traitements plus efficaces et cibl\u00e9s.<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false},"tags":[],"project-category":[125],"class_list":["post-4748","theme-project","type-theme-project","status-publish","hentry","project-category-biologie-du-cancer"],"acf":[],"yoast_head":"\n\u00c9valuation de la podocalyxine comme biomarqueur th\u00e9rapeutique pour un n\u00e9phroblastome agressif - Access<\/title>\n<meta name=\"description\" content=\"ACCESS is organized into seven research themes from understanding cancer development to its diagnosis, treatment, and survivorship and two cross-cutting groups to support all thematic areas.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/evaluation-de-la-podocalyxine-comme-biomarqueur-therapeutique-pour-un-nephroblastome-agressif\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c9valuation de la podocalyxine comme biomarqueur th\u00e9rapeutique pour un n\u00e9phroblastome agressif - 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