{"id":3845,"date":"2025-07-24T17:05:18","date_gmt":"2025-07-24T21:05:18","guid":{"rendered":"https:\/\/www.accessforkidscancer.ca\/?post_type=theme-project&p=3845"},"modified":"2025-11-21T11:51:37","modified_gmt":"2025-11-21T16:51:37","slug":"programme-de-modelisation-preclinique-pediatrique","status":"publish","type":"theme-project","link":"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/programme-de-modelisation-preclinique-pediatrique\/","title":{"rendered":"Programme de mod\u00e9lisation <\/span> pr\u00e9clinique p\u00e9diatrique"},"content":{"rendered":"

Le traitement du cancer est un processus ardu pour l\u2019esprit et le corps d\u2019un patient, en particulier ceux qui sont encore dans l\u2019enfance, l\u2019adolescence et le jeune \u00e2ge adulte (CAYA). La chimioth\u00e9rapie standard affecte \u00e0 la fois les cellules canc\u00e9reuses et les cellules saines, produisant un large \u00e9ventail d\u2019effets secondaires, dont certains peuvent avoir des r\u00e9percussions durables sur la vie d\u2019un patient. Par cons\u00e9quent, des traitements cibl\u00e9s qui peuvent affecter plus sp\u00e9cifiquement les cellules canc\u00e9reuses sont souhaitables pour une \u00e9limination plus s\u00fbre et plus efficace de la tumeur. Cependant, l\u2019utilisation de th\u00e9rapies cibl\u00e9es n\u00e9cessite que la tumeur en question soit \u00e9tudi\u00e9e et test\u00e9e en profondeur. Pour cette raison, de nombreux patients re\u00e7oivent une chimioth\u00e9rapie standard et l\u2019efficacit\u00e9 du traitement est d\u00e9termin\u00e9e par un syst\u00e8me d\u2019essais et d\u2019erreurs. Cela peut entra\u00eener plusieurs cycles longs et difficiles de chimioth\u00e9rapie g\u00e9n\u00e9rale, entra\u00eenant des effets secondaires importants et potentiellement une rechute.<\/p>\n

Tout cela d\u00e9montre le grand besoin d\u2019options de traitement personnalis\u00e9es, afin de trouver un moyen de d\u00e9terminer de mani\u00e8re fiable quels traitements fonctionneront pour chaque patient tout en minimisant la quantit\u00e9 de traitement administr\u00e9e au patient lui-m\u00eame. C\u2019est l\u00e0 que le Programme de mod\u00e9lisation pr\u00e9clinique p\u00e9diatrique entend faire une diff\u00e9rence. Dans le cadre de ce projet, le th\u00e8me de recherche Biologie du cancer vise \u00e0 r\u00e9unir plusieurs des plus grands experts canadiens dans le domaine afin de d\u00e9velopper et d\u2019utiliser des mod\u00e8les animaux afin d\u2019identifier des traitements sp\u00e9cifiques qui ciblent la composition unique de la tumeur de chaque patient avant de l\u2019administrer.<\/p>\n

Objectifs\u00a0:<\/p>\n

    \n
  1. D\u00e9velopper et mettre en \u0153uvre un pipeline pr\u00e9clinique multimod\u00e8le efficace qui peut \u00e9valuer rapidement les traitements personnalis\u00e9s, standard et nouveaux, pour chaque patient peu apr\u00e8s le diagnostic;<\/li>\n
  2. D\u00e9velopper et comparer plusieurs mod\u00e8les in vitro<\/em> et animaux diff\u00e9rents (poisson-z\u00e8bre, embryons de poussin et souris) pour une grande vari\u00e9t\u00e9 de cancers CAYA, y compris les tumeurs solides, les h\u00e9mopathies malignes ainsi que les tumeurs rares et \u00e0 haut risque;<\/li>\n
  3. Cr\u00e9er une biobanque virtuelle annot\u00e9e de mod\u00e8les animaux pour la recherche \u00e0 long terme;<\/li>\n
  4. Accro\u00eetre l\u2019acc\u00e8s \u00e0 des tests de traitement personnalis\u00e9s partout au Canada, peu importe l\u2019emplacement, la race ou l\u2019origine ethnique.<\/li>\n<\/ol>\n

    Dans l\u2019ensemble, ce projet vise \u00e0 rendre le traitement du cancer aussi efficace que possible pour certaines de nos populations les plus vuln\u00e9rables. Cela comprend l\u2019am\u00e9lioration de la survie et de la qualit\u00e9 de vie, ainsi que l\u2019am\u00e9lioration de l\u2019acc\u00e8s \u00e0 ces traitements dans tout le pays. De plus, ce programme vise \u00e0 \u00e9largir et \u00e0 relier le r\u00e9seau actuel de chercheurs et \u00e0 cr\u00e9er de nouveaux outils qui am\u00e9lioreront l\u2019efficacit\u00e9 et l\u2019efficience de la recherche pr\u00e9clinique sur le cancer \u00e0 l\u2019avenir.<\/p>\n

    Partenaires financiers :<\/h4>\n

    BC Children’s Hospital Foundation<\/a>.<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"tags":[],"project-category":[125],"class_list":["post-3845","theme-project","type-theme-project","status-publish","hentry","project-category-biologie-du-cancer"],"acf":[],"yoast_head":"\nProgramme de mod\u00e9lisation pr\u00e9clinique p\u00e9diatrique - Access<\/title>\n<meta name=\"description\" content=\"ACCESS is organized into seven research themes from understanding cancer development to its diagnosis, treatment, and survivorship and two cross-cutting groups to support all thematic areas.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/programme-de-modelisation-preclinique-pediatrique\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Programme de mod\u00e9lisation pr\u00e9clinique p\u00e9diatrique - 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