{"id":3673,"date":"2025-04-17T11:54:08","date_gmt":"2025-04-17T15:54:08","guid":{"rendered":"https:\/\/www.accessforkidscancer.ca\/?post_type=theme-project&#038;p=3673"},"modified":"2025-12-12T12:22:47","modified_gmt":"2025-12-12T17:22:47","slug":"lessai-optimise","status":"publish","type":"theme-project","link":"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/lessai-optimise\/","title":{"rendered":"L\u2019essai  <span> OPTIMISE <\/span>"},"content":{"rendered":"<p>La mise au point d\u2019approches d\u2019oncologie de pr\u00e9cision a \u00e9t\u00e9 l\u2019une des principales avanc\u00e9es scientifiques visant \u00e0 am\u00e9liorer les r\u00e9sultats pour les enfants, les adolescents et les jeunes adultes (EAJA) atteints de cancer en leur permettant de mieux comprendre les bases mol\u00e9culaires de leurs cancers et en offrant un aper\u00e7u des nouvelles th\u00e9rapies potentielles. Partout au Canada, le projet pilote d\u2019ACCES, <a href=\"https:\/\/www.accessforkidscancer.ca\/fr\/driver-project\/precision-oncology-for-young-people-profyle\/\">PROFYLE<\/a>, offre le s\u00e9quen\u00e7age du g\u00e9nome et du transcriptome et des analyses bio-informatiques pour tous les patients atteints d\u2019un cancer \u00ab\u00a0difficile \u00e0 gu\u00e9rir\u00a0\u00bb. \u00c0 ce jour, plus de 40\u00a0% des patients s\u00e9quenc\u00e9s par PROFYLE ont obtenu un r\u00e9sultat potentiellement exploitable.<\/p>\n<p>Cependant, il n\u2019y a pas de m\u00e9canisme \u00e9tabli permettant \u00e0 ces patients dont les r\u00e9sultats pourraient \u00eatre exploitables au Canada de recevoir un traitement cibl\u00e9 correspondant, principalement en raison du manque d\u2019essais cliniques \u00e9clair\u00e9s sur le plan mol\u00e9culaire pour les EAJA atteints d\u2019un cancer. Bien qu\u2019il y ait eu une augmentation globale du nombre d\u2019essais de plateformes d\u2019oncologie de pr\u00e9cision dans lesquels plusieurs nouvelles th\u00e9rapies peuvent \u00eatre test\u00e9es simultan\u00e9ment dans des populations de patients relativement petites, il y a encore peu de possibilit\u00e9s d\u2019essais de plateforme pour les EAJA atteints d\u2019un cancer malgr\u00e9 un besoin non satisfait de plus en plus d\u00e9montr\u00e9 dans cette population. De plus, les quelques essais portant sur les plateformes d\u2019oncologie de pr\u00e9cision propres aux EAJA qui existent \u2013 provenant des \u00c9tats-Unis et de l\u2019Europe \u2013 n\u2019ont pas \u00e9t\u00e9 ouverts dans les centres de canc\u00e9rologie p\u00e9diatrique canadiens en raison de d\u00e9fis r\u00e9glementaires et de limites sur la distribution des m\u00e9dicaments.<\/p>\n<p>En collaboration avec des coll\u00e8gues de <a href=\"https:\/\/www.zerochildhoodcancer.org.au\/\">ZERO Childhood Cancer<\/a> en Australie, l\u2019essai OPTIMIZE (Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer) a \u00e9t\u00e9 d\u00e9velopp\u00e9 sous la forme d\u2019un essai de plateforme multibras qui d\u00e9veloppera et testera de nouvelles th\u00e9rapies pour les patients admissibles identifi\u00e9s par s\u00e9quen\u00e7age multiomique dans le cadre d\u2019un programme national de s\u00e9quen\u00e7age du cancer chez les EAJA, comme PROFYLE et ZERO Childhood Cancer.<\/p>\n<p>L\u2019essai OPTIMIZE aidera \u00e0 faciliter l\u2019adoption des recommandations de traitement de PROFYLE et de ZERO Childhood Cancer, permettant l\u2019\u00e9valuation de nouveaux agents mol\u00e9culaires cibl\u00e9s. Nous esp\u00e9rons que cela m\u00e8nera \u00e0 une am\u00e9lioration des taux de r\u00e9ponse tumorale et \u00e0 la survie sans \u00e9volution pour les patients ayant des r\u00e9sultats mol\u00e9culaires pertinents, ainsi qu\u2019\u00e0 une meilleure compr\u00e9hension de la r\u00e9ponse au traitement et des m\u00e9canismes de r\u00e9sistance de la r\u00e9ponse. Ainsi, cet essai constituera la prochaine \u00e9tape cruciale de l\u2019application des progr\u00e8s de la g\u00e9nomique clinique \u00e0 la mise \u00e0 l\u2019essai de th\u00e9rapies mol\u00e9culaires cibl\u00e9es novatrices pour les patients atteints de cancer au Canada.<\/p>\n<p>Le th\u00e8me de recherche Essais cliniques d\u2019ACCES vise \u00e0 faciliter une plus grande participation \u00e0 l\u2019essai OPTIMIZE \u00e0 l\u2019\u00e9chelle du Canada.\u00a0 L\u2019essai sera ouvert dans un maximum de six centres canadiens et int\u00e9grera l\u2019utilisation de sites satellites dans la mesure du possible, afin de minimiser le temps de d\u00e9placement des patients et des familles et d\u2019accro\u00eetre la participation des communaut\u00e9s qui ont \u00e9t\u00e9 historiquement sous-repr\u00e9sent\u00e9es dans les essais cliniques.<\/p>\n<h4 style=\"color: #6251d3;\">Partenaires financiers :<\/h4>\n<p><a href=\"https:\/\/anzchog.org\/\" target=\"_blank\" rel=\"noopener\">Australian &amp; New Zealand Children&rsquo;s Haematology\/Oncology Group<\/a>, <a href=\"https:\/\/cancer.ca\/fr\/\" target=\"_blank\" rel=\"noopener\">Soci\u00e9t\u00e9 canadienne du cancer<\/a>, et <a href=\"https:\/\/cihr-irsc.gc.ca\/f\/193.html\" target=\"_blank\" rel=\"noopener\">Les Instituts de recherche en sant\u00e9 du Canada<\/a>.<\/p>\n<p><strong><span class=\"info-provided-title\">ClinicalTrials.gov ID: <\/span><i class=\"icon-display\" tabindex=\"0\" title=\"Opens glossary for clinicaltrials.gov identifier (nct number)\" aria-hidden=\"false\" aria-label=\"opens glossary for clinicaltrials.gov identifier (nct number)\" data-term=\"clinicaltrials.gov identifier (nct number)\"><\/i><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06208657?term=optimise&amp;locStr=Canada&amp;country=Canada&amp;rank=6\"><span class=\"padding-left-05\">NCT06208657<\/span><\/a><\/strong><\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"tags":[],"project-category":[126],"class_list":["post-3673","theme-project","type-theme-project","status-publish","hentry","project-category-essais-cliniques"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>L\u2019essai  OPTIMISE  - Access<\/title>\n<meta name=\"description\" content=\"ACCESS is organized into seven research themes from understanding cancer development to its diagnosis, treatment, and survivorship and two cross-cutting groups to support all thematic areas.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/lessai-optimise\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L\u2019essai  OPTIMISE  - Access\" \/>\n<meta property=\"og:description\" content=\"ACCESS is organized into seven research themes from understanding cancer development to its diagnosis, treatment, and survivorship and two cross-cutting groups to support all thematic areas.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/lessai-optimise\/\" \/>\n<meta property=\"og:site_name\" content=\"Access\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-12T17:22:47+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.accessforkidscancer.ca\/wp-content\/uploads\/2024\/08\/access-site-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@acces_access\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/lessai-optimise\/\",\"url\":\"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/lessai-optimise\/\",\"name\":\"L\u2019essai OPTIMISE - Access\",\"isPartOf\":{\"@id\":\"http:\/\/www.accessforkidscancer.ca\/fr\/#website\"},\"datePublished\":\"2025-04-17T15:54:08+00:00\",\"dateModified\":\"2025-12-12T17:22:47+00:00\",\"description\":\"ACCESS is organized into seven research themes from understanding cancer development to its diagnosis, treatment, and survivorship and two cross-cutting groups to support all thematic areas.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/lessai-optimise\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/lessai-optimise\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/lessai-optimise\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"http:\/\/www.accessforkidscancer.ca\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"L\u2019essai OPTIMISE\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.accessforkidscancer.ca\/fr\/#website\",\"url\":\"http:\/\/www.accessforkidscancer.ca\/fr\/\",\"name\":\"ACCESS\",\"description\":\"Advancing Childhood Cancer Experience, Science &amp; 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