{"id":3672,"date":"2025-04-17T11:48:22","date_gmt":"2025-04-17T15:48:22","guid":{"rendered":"https:\/\/www.accessforkidscancer.ca\/?post_type=theme-project&p=3672"},"modified":"2026-02-03T11:24:39","modified_gmt":"2026-02-03T16:24:39","slug":"lessai-decrypt","status":"publish","type":"theme-project","link":"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/lessai-decrypt\/","title":{"rendered":"L\u2019essai DECRYPT <\/span> Babybrain"},"content":{"rendered":"

Les tumeurs c\u00e9r\u00e9brales embryonnaires (TCE) constituent la plus grande cat\u00e9gorie de tumeurs malignes du syst\u00e8me nerveux central (SNC) chez les enfants de 0 \u00e0 14\u00a0ans, et comprennent un certain nombre de tumeurs c\u00e9r\u00e9brales agressives et mortelles qui doivent recevoir des soins pr\u00e9cis en temps opportun. Environ 60\u00a0% des TCE sont consid\u00e9r\u00e9s comme des maladies rares \u00e0 risque \u00e9lev\u00e9 et \u00e0 mortalit\u00e9 \u00e9lev\u00e9e chez les enfants de moins de 3 \u00e0 6\u00a0ans (\u00ab\u00a0nourrissons\u00a0\u00bb). En fait, malgr\u00e9 la chimioth\u00e9rapie et la radioth\u00e9rapie intensives, qui ont des cons\u00e9quences physiques et cognitives d\u00e9vastatrices \u00e0 long terme, seule une petite fraction (10 \u00e0 35\u00a0%) des patients atteints d\u2019une TCE survivent \u00e0 long terme.<\/p>\n

Des \u00e9quipes dirig\u00e9es par des Canadiens ont \u00e9t\u00e9 \u00e0 l\u2019avant-garde de la lutte contre ces cancers difficiles et de leur compr\u00e9hension. Il est important de noter que des chercheurs de l\u2019Hospital for Sick Children (SickKids) ont mis au point un nouveau sch\u00e9ma th\u00e9rapeutique sans radioth\u00e9rapie (SickKids Standard of Care [SKSOC]). Ce sch\u00e9ma comprend une th\u00e9rapie intrath\u00e9cale directe, au cours de laquelle la chimioth\u00e9rapie est administr\u00e9e dans les liquides autour du cerveau, et l\u2019ajout d\u2019un sch\u00e9ma chimioth\u00e9rapeutique m\u00e9tronomique apr\u00e8s une chimioth\u00e9rapie \u00e0 forte dose. Le sch\u00e9ma th\u00e9rapeutique SKSOC a am\u00e9lior\u00e9 la survie sans radioth\u00e9rapie chez 60\u00a0% des patients, ce qui est important en raison de la toxicit\u00e9 neurocognitive n\u00e9faste de la radioth\u00e9rapie dans les jeunes cerveaux. Ce sch\u00e9ma th\u00e9rapeutique unique a \u00e9t\u00e9 adopt\u00e9 comme pratique exemplaire partout au Canada et est utilis\u00e9 dans de nombreux autres centres \u00e0 l\u2019ext\u00e9rieur du Canada. Bien que ce succ\u00e8s soit passionnant, il est temp\u00e9r\u00e9 par le manque de connaissances et d\u2019outils pour d\u00e9terminer quels facteurs biologiques ou cliniques permettent de pr\u00e9dire le succ\u00e8s ou l\u2019\u00e9chec du traitement et par l\u2019absence de donn\u00e9es prospectives multi-institutionnelles.<\/p>\n

\u00c0 ce titre, l\u2019essai canadien DECRYPT (Defeating Embryonal Cancer in Young People Together) \u2013 BABYBRAIN, avec le parrainage du C17\u00a0Council, \u00e9valuera l\u2019innocuit\u00e9 et la tol\u00e9rabilit\u00e9 du sch\u00e9ma th\u00e9rapeutique SKSOC pour les patients de moins de 6\u00a0ans diagnostiqu\u00e9s avec une TCE du SNC \u00e0 haut risque au Canada. L\u2019essai permettra \u00e9galement de mettre en place une plateforme nationale de discussion pour tous les jeunes patients atteints de TCE \u00e0 haut risque, ainsi que la collecte et l\u2019analyse de tissus tumoraux et de liquides c\u00e9phalorachidiens, ce qui permettra de transmettre en temps r\u00e9el les renseignements n\u00e9cessaires pour adapter les traitements afin qu\u2019ils soient plus efficaces et moins toxiques \u00e0 l\u2019avenir pour les jeunes patients diagnostiqu\u00e9s avec une TCE \u00e0 haut risque.<\/p>\n

Cet essai repr\u00e9sente la premi\u00e8re \u00e9tape vers le d\u00e9veloppement d\u2019une plateforme nationale d\u2019essais cliniques de la m\u00e9decine de pr\u00e9cision sur les cancers du cerveau chez les nourrissons, dirig\u00e9e par un groupe multipartite compos\u00e9 d\u2019experts en soins de sant\u00e9 et en recherche et de patients partenaires. On esp\u00e8re que gr\u00e2ce au partage des connaissances, des ressources et de l\u2019acc\u00e8s aux soins de sant\u00e9, non seulement les soins et les r\u00e9sultats pancanadiens pour les nourrissons atteints d\u2019un cancer du cerveau s\u2019am\u00e9lioreront, mais une plateforme puissante pour lancer des essais futurs similaires sera \u00e9tablie.<\/p>\n

L\u2019essai provient d\u2019une coalition d\u2019organismes de bienfaisance canadiens et de bailleurs de fonds nationaux de la recherche par l\u2019entremise de la subvention de recherche DECRYPT. Ceux-ci en assurent \u00e9galement le soutien. Cette subvention unique a \u00e9t\u00e9 rendue possible gr\u00e2ce \u00e0 un partenariat entre la Kindred Foundation, la Soci\u00e9t\u00e9 de recherche sur le cancer, Phoebe Rose Rocks, la Fondation canadienne des tumeurs c\u00e9r\u00e9brales, la Miracle Marnie Foundation, la Fondation canadienne du cancer chez l\u2019enfant et Tali\u2019s Fund.<\/p>\n

S\u2019ajoutant \u00e0 ce soutien continu, le th\u00e8me de recherche Essais cliniques d\u2019ACCES vise \u00e0 faciliter la participation de tous les enfants admissibles \u00e0 cet essai. Pour ce faire, on aidera les chercheurs charg\u00e9s de l\u2019essai \u00e0 mettre en place cet essai dans le plus grand nombre possible des 16\u00a0centres de canc\u00e9rologie p\u00e9diatrique du Canada et on int\u00e9grera l\u2019utilisation de sites satellites dans la mesure du possible, afin de minimiser le temps de d\u00e9placement des patients et des familles et d\u2019accro\u00eetre la participation des communaut\u00e9s qui ont \u00e9t\u00e9 historiquement sous-repr\u00e9sent\u00e9es dans les essais cliniques.<\/p>\n

Partenaires financiers :<\/h4>\n

Kindred Foundation<\/a>, Cancer Research Society<\/a>, Phoebe Rose Rocks<\/a>, Brain Tumour Foundation of Canada<\/a>, The Miracle Marnie Foundation<\/a>, Childhood Cancer Canada<\/a>, and Tali\u2019s Fund<\/a>.<\/p>\n

ClinicalTrials.gov ID: <\/span>NCT06942039<\/span><\/a><\/strong><\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"tags":[],"project-category":[126],"class_list":["post-3672","theme-project","type-theme-project","status-publish","hentry","project-category-essais-cliniques"],"acf":[],"yoast_head":"\nL\u2019essai DECRYPT Babybrain - Access<\/title>\n<meta name=\"description\" content=\"ACCESS is organized into seven research themes from understanding cancer development to its diagnosis, treatment, and survivorship and two cross-cutting groups to support all thematic areas.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/lessai-decrypt\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L\u2019essai DECRYPT Babybrain - 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