{"id":3670,"date":"2025-04-17T11:42:40","date_gmt":"2025-04-17T15:42:40","guid":{"rendered":"https:\/\/www.accessforkidscancer.ca\/?post_type=theme-project&p=3670"},"modified":"2025-12-12T12:18:37","modified_gmt":"2025-12-12T17:18:37","slug":"essai-victory","status":"publish","type":"theme-project","link":"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/essai-victory\/","title":{"rendered":"L’essai VICTORY <\/span>"},"content":{"rendered":"

Les gliomes p\u00e9diatriques de bas grade (PLGG) sont le type le plus courant de tumeur c\u00e9r\u00e9brale chez les enfants; il est compos\u00e9 de plusieurs sous-types de tumeurs distinctes qui repr\u00e9sentent environ le tiers de toutes les tumeurs c\u00e9r\u00e9brales chez les enfants. Les PLGG ont des caract\u00e9ristiques biologiques agressives, se d\u00e9veloppent lentement et ont souvent un bon pronostic s\u2019ils sont compl\u00e8tement enlev\u00e9s par chirurgie. Cependant, ils apparaissent souvent profond\u00e9ment dans le cerveau ou \u00e0 proximit\u00e9 de structures vitales, y compris les voies optiques et le tronc c\u00e9r\u00e9bral, ce qui rend difficile leur ablation chirurgicale compl\u00e8te.<\/p>\n

Par cons\u00e9quent, les enfants atteints d\u2019un PLGG non r\u00e9s\u00e9cable ou r\u00e9cidivant ont souvent besoin d\u2019un traitement suppl\u00e9mentaire. Bien que la radioth\u00e9rapie ait toujours \u00e9t\u00e9 la norme de soins, la chimioth\u00e9rapie est devenue le traitement de premi\u00e8re ligne privil\u00e9gi\u00e9 au cours des derni\u00e8res ann\u00e9es en raison des pr\u00e9occupations concernant la toxicit\u00e9 \u00e0 long terme chez les enfants induite par la radioth\u00e9rapie. . Plusieurs sch\u00e9mas chimioth\u00e9rapeutiques diff\u00e9rents sont actuellement utilis\u00e9s, mais les taux de survie sans \u00e9v\u00e9nement (SSE) \u00e0 5\u00a0ans avec ces sch\u00e9mas sont de l\u2019ordre de 40\u00a0% et la plupart des enfants ont besoin de plusieurs cycles de chimioth\u00e9rapie. Ces traitements prolong\u00e9s ou multiples sont associ\u00e9s \u00e0 une morbidit\u00e9 importante, ce qui a des r\u00e9percussions majeures sur le d\u00e9veloppement et la qualit\u00e9 de vie globale de ces patients. Par cons\u00e9quent, il existe un besoin crucial en mati\u00e8re d\u2019options de traitement plus efficaces et moins toxiques pour cette vaste population de patients<\/p>\n

L\u2019activation de la voie de la kinase RAS\/RAF\/MEK\/ERK a \u00e9t\u00e9 identifi\u00e9e dans presque tous les PLGG, quelle que soit leur structure biologique. Les traitements ciblant cette voie ont \u00e9t\u00e9 utilis\u00e9s avec succ\u00e8s chez les patients atteints de PLGG r\u00e9cidivants et les taux de r\u00e9ponse observ\u00e9s dans les essais en phase pr\u00e9coce r\u00e9cemment publi\u00e9s sont prometteurs. Cependant, l\u2019\u00e9volution de la tumeur apr\u00e8s l\u2019interruption du traitement demeure un d\u00e9fi important lorsqu\u2019il s\u2019agit d\u2019arr\u00eater le traitement. La combinaison d\u2019inhibiteurs de la voie de la kinase\u00a0RAS\/RAF\/MEK\/ERK et de la chimioth\u00e9rapie a montr\u00e9 une synergie favorable et des toxicit\u00e9s qui ne se chevauchent pas dans les mod\u00e8les pr\u00e9cliniques et, par cons\u00e9quent, pourrait pr\u00e9senter une nouvelle option de traitement pour les enfants atteints de PLGG.<\/p>\n

L\u2019essai VICTORY, dirig\u00e9 par le Canada, est un essai pilote, multicentrique et ouvert qui utilise cette nouvelle strat\u00e9gie pour combiner la chimioth\u00e9rapie et le traitement cibl\u00e9 afin de v\u00e9rifier si elle est non seulement s\u00fbre, mais aussi plus efficace.\u00a0\u00a0 L\u2019essai vise \u00e0 d\u00e9terminer la dose maximale tol\u00e9r\u00e9e de vinblastine, une chimioth\u00e9rapie, avec le tovorafenib, un nouvel inhibiteur de RAF qui n\u2019est pas actuellement disponible pour les patients p\u00e9diatriques atteints de cancer au Canada atteints de PLGG r\u00e9cidivants.\u00a0 L\u2019essai \u00e9valuera \u00e9galement l\u2019efficacit\u00e9 de cette combinaison, mais en examinant le taux de r\u00e9ponse global et la survie sans \u00e9volution chez les enfants atteints de PLGG r\u00e9cidivants ou \u00e9volutifs.<\/p>\n

L\u2019\u00e9quipe de l\u2019essai s\u2019est engag\u00e9e \u00e0 faciliter la participation de tous les enfants admissibles \u00e0 cet essai. Pour ce faire, on fera appel \u00e0 au moins neuf centres canadiens et l\u2019utilisation de sites satellites sera int\u00e9gr\u00e9e, dans la mesure du possible, afin de r\u00e9duire au minimum le temps de d\u00e9placement des patients et des familles, dans le but d\u2019am\u00e9liorer la sensibilisation des communaut\u00e9s et des minorit\u00e9s historiquement sous-repr\u00e9sent\u00e9es dans les essais cliniques.<\/p>\n

Partenaires financiers :<\/h4>\n

Instituts de recherche en sant\u00e9 du Canada<\/a>.<\/p>\n

ClinicalTrials.gov ID: <\/span><\/i>NCT06381570<\/span><\/a><\/strong><\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"tags":[],"project-category":[126],"class_list":["post-3670","theme-project","type-theme-project","status-publish","hentry","project-category-essais-cliniques"],"acf":[],"yoast_head":"\nL'essai VICTORY - Access<\/title>\n<meta name=\"description\" content=\"ACCESS is organized into seven research themes from understanding cancer development to its diagnosis, treatment, and survivorship and two cross-cutting groups to support all thematic areas.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/essai-victory\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L'essai VICTORY - 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