{"id":2845,"date":"2024-07-06T04:27:29","date_gmt":"2024-07-06T08:27:29","guid":{"rendered":"https:\/\/demo.creativeisk.com\/access_dev\/?post_type=theme-project&#038;p=2845"},"modified":"2025-12-12T12:13:23","modified_gmt":"2025-12-12T17:13:23","slug":"essai-mirv","status":"publish","type":"theme-project","link":"http:\/\/www.accessforkidscancer.ca\/fr\/projects\/essai-mirv\/","title":{"rendered":"L&rsquo;essai <span>MIRV<\/span>"},"content":{"rendered":"<p>Les gliomes p\u00e9diatriques de bas grade (PLGG) sont les tumeurs c\u00e9r\u00e9brales les plus courantes chez les enfants et n\u00e9cessitent souvent un traitement syst\u00e9mique, car ils sont inop\u00e9rables en raison de leur emplacement. Actuellement, la chimioth\u00e9rapie constitue le soin standard, quoiqu\u2019avec un faible taux de r\u00e9ponse et une \u00e9volution fr\u00e9quente de la maladie apr\u00e8s le traitement initial.<\/p>\n<p>Des essais cliniques ant\u00e9rieurs indiquent que les inhibiteurs de la MEK (MEKi), lorsqu\u2019ils sont utilis\u00e9s seuls pour les patients atteints de PLGG r\u00e9cidivant, r\u00e9fractaire ou progressif, entra\u00eenent une r\u00e9duction de la taille de la tumeur de plus de 70\u00a0pour\u00a0cent et offrent une excellente tol\u00e9rance et une excellente qualit\u00e9 de vie. Pour d\u00e9velopper ces r\u00e9sultats remarquables, le th\u00e8me Essais cliniques d\u2019ACCES soutient un essai clinique unique en son genre qui vise \u00e0 r\u00e9volutionner les options de traitement pour les patients nouvellement diagnostiqu\u00e9s atteints de PLGG en utilisant une approche combin\u00e9e (chimioth\u00e9rapie plus MEKi) pour le traitement.<\/p>\n<p>L\u2019essai clinique multicentrique de phase 1\/2 du MIRV (MIRdametinib et Vinblastine) dirig\u00e9 par le Canada \u00e9valuera l\u2019innocuit\u00e9 et l\u2019efficacit\u00e9 du mirdametinib, un MEKi combin\u00e9 \u00e0 la vinblastine (chimioth\u00e9rapie) chez des patients nouvellement diagnostiqu\u00e9s atteints de PLGG.<\/p>\n<p>L\u2019objectif principal de l\u2019essai est de d\u00e9terminer l\u2019effet de la th\u00e9rapie combin\u00e9e sur la r\u00e9duction de la tumeur. Les objectifs secondaires de l\u2019essai comprennent l\u2019\u00e9valuation de l\u2019innocuit\u00e9 et de la tol\u00e9rabilit\u00e9 de la polyth\u00e9rapie ainsi que l\u2019\u00e9valuation de l\u2019incidence de la th\u00e9rapie combin\u00e9e sur la survie, l\u2019\u00e9volution de la maladie et la fonction neurologique.<\/p>\n<p>Le th\u00e8me de recherche Essais cliniques se consacre \u00e0 faciliter la participation de chaque enfant admissible \u00e0 cet essai et \u00e0 accorder aux patients atteints de PLGG un ACCES au traitement le plus r\u00e9cent et le plus prometteur. Pour ce faire, on fera appel \u00e0 au moins neuf centres canadiens et l\u2019utilisation de sites satellites sera int\u00e9gr\u00e9e, dans la mesure du possible, afin de r\u00e9duire au minimum le temps de d\u00e9placement des patients et des familles, dans le but d\u2019am\u00e9liorer la sensibilisation des communaut\u00e9s et des minorit\u00e9s historiquement sous-repr\u00e9sent\u00e9es dans les essais cliniques.<\/p>\n<h4 style=\"color: #6251d3;\">Partenaires financiers :<\/h4>\n<p><a href=\"https:\/\/cihr-irsc.gc.ca\/f\/193.html\" target=\"_blank\" rel=\"noopener\">Les Instituts de recherche en sant\u00e9 du Canada<\/a>, <a href=\"https:\/\/recherche.chusj.org\/fr\/Axes-de-recherche\/Possibilites-de-financements\/Fonds-Benoit-Lanteigne-pour-le-developpement-de-t\" target=\"_blank\" rel=\"noopener\">Fonds Benoit Lanteigne<\/a>, <a href=\"https:\/\/fondationrecherchepediatrique.ca\/\" target=\"_blank\" rel=\"noopener\">Fondation des \u00c9toiles<\/a>, et <a href=\"https:\/\/springworkstx.com\/\" target=\"_blank\" rel=\"noopener\">SpringWorks Therapeutics<\/a>.<\/p>\n<p><strong><span class=\"info-provided-title\">ClinicalTrials.gov ID: <\/span><i class=\"icon-display\" tabindex=\"0\" title=\"Opens glossary for clinicaltrials.gov identifier (nct number)\" aria-hidden=\"false\" aria-label=\"opens glossary for clinicaltrials.gov identifier (nct number)\" data-term=\"clinicaltrials.gov identifier (nct number)\"><\/i><a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT06666348?term=perreault&amp;rank=4\"><span class=\"padding-left-05\">NCT06666348<\/span><\/a><\/strong><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"tags":[],"project-category":[126],"class_list":["post-2845","theme-project","type-theme-project","status-publish","hentry","project-category-essais-cliniques"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - 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